%0 journal article
%@ 1742-464X
%A Linser, S., Funari, S.S., Willumeit, R.

%D 2006
%J The FEBS Journal

%P 70 
%R doi:10.1111/j.1742-4658.2006.05276.x
%T Development Of New Antimicrobial Peptides And Their Interaction With Model Membranes
%U https://doi.org/10.1111/j.1742-4658.2006.05276.x
 
%X We found NK-CS to be a very potent antimicrobial peptide, while none of the derivatives showed improved antibacterial selectivity and activity. Structural characterization of the interaction between the peptide and model membranes revealed that for all tested peptides the inverse hexagonal phase transition of phosphatidylethanolamine lipids was altered in a specific manner which can be correlated with the activity of the peptides. This phase transition temperature was increased by the peptides meaning the promotion of a positive curvature of the membranes. We assume that, as it was found for Magainins, this curvature finally leads to the disruption of the model membranes.