%0 journal article %@ 0009-5893 %A Siwek, M., Noubar, A.B., Erdmann, R., Niemeyer, B., Galunsky, B. %D 2008 %J Chromatographia %N 3-4 %P 305-308 %R doi:10.1365/s10337-007-0494-1 %T Application of Mixed-Mode Oasis MCX Adsorbent for Chromatographic Separation of Selenomethionine from Antarctic Krill After Enzymatic Digestion %U https://doi.org/10.1365/s10337-007-0494-1 3-4 %X The present communication describes the novel application of mixed-mode adsorbents for bifunctional chromatography. Oasis MCX mixed-mode adsorbent (Waters GmbH, Eschborn, Germany) shows a high binding capacity for Se-Met. The adsorbed selenoamino acid is easily eluted by pH change and addition of organic solvent. Determined adsorption isotherm parameters are suitable for its analytical and preparative chromatographic isolation. A chromatographic column packed with the Oasis MCX adsorbent, designed for a single use solid phase extraction, was successfully applied for bifunctional chromatographic separation of Se-Met from hydrolysed Antarctic krill samples with 85 ± 5% recovery. The MCX-packed column was used for more than 60 runs without any change in its performance.