@misc{kochanowski_examination_of_2011, 
author={Kochanowski, A., Hoene, A., Patrzyk, M., Walschus, U., Finke, B., Luthringer, B., Feyerabend, F., Willumeit, R., Lucke, S., Schlosser, M.},
title={Examination of the inflammatory response following implantation of titanium plates coated with phospholipids in rats},
year={2011},
howpublished = {journal article},
doi = {https://doi.org/10.1007/s10856-011-4287-6},
abstract = {Implantation of biomaterials like titanium (Ti) causes inflammatory reactions possibly affecting implant functionality. Surface modifications could improve biocompatibility and functionality of implants. Biomembrane-derived phospholipids might be useful as implant coating due to their biomimetic properties. In vitro studies demonstrated beneficial effects for 2-oleoyl-1-palmitoyl-sn-glycero-3-phosphoethanolamin (POPE) as coating regarding interactions with cells and bacteria. Therefore, this in vivo study aimed at examining local inflammatory reactions after implantation of POPE-coated Ti plates. Ti implants with POPE attached non-covalently or covalent via octadecylphosphonic acid (OPA), with OPA alone and uncoated controls were simultaneously implanted intramuscularly in rats for 7, 14 and 56 days. The peri-implant tissue was quantitatively analyzed by immunohistochemistry for total macrophages, tissue macrophages, T cells, antigen-presenting cells and proliferating cells. Overall, both POPE-coated series were comparable to the controls. Furthermore, no differences were found between POPE coating on a covalently linked OPA monolayer and POPE coating dried from solution. Together with earlier in vitro results, this demonstrates the potential of phospholipids for implant surface modification.},
note = {Online available at: \url{https://doi.org/10.1007/s10856-011-4287-6} (DOI). Kochanowski, A.; Hoene, A.; Patrzyk, M.; Walschus, U.; Finke, B.; Luthringer, B.; Feyerabend, F.; Willumeit, R.; Lucke, S.; Schlosser, M.: Examination of the inflammatory response following implantation of titanium plates coated with phospholipids in rats. Journal of Materials Science: Materials in Medicine. 2011. vol. 22, no. 4, 1015-1026. DOI: 10.1007/s10856-011-4287-6}}