%0 journal article
%@ 0957-4530
%A Kochanowski, A., Hoene, A., Patrzyk, M., Walschus, U., Finke, B., Luthringer, B., Feyerabend, F., Willumeit, R., Lucke, S., Schlosser, M.

%D 2011
%J Journal of Materials Science: Materials in Medicine
%N 4
%P 1015-1026 
%R doi:10.1007/s10856-011-4287-6
%T Examination of the inflammatory response following implantation of titanium plates coated with phospholipids in rats
%U https://doi.org/10.1007/s10856-011-4287-6
4 
%X Implantation of biomaterials like titanium (Ti) causes inflammatory reactions possibly affecting implant functionality. Surface modifications could improve biocompatibility and functionality of implants. Biomembrane-derived phospholipids might be useful as implant coating due to their biomimetic properties. In vitro studies demonstrated beneficial effects for 2-oleoyl-1-palmitoyl-sn-glycero-3-phosphoethanolamin (POPE) as coating regarding interactions with cells and bacteria. Therefore, this in vivo study aimed at examining local inflammatory reactions after implantation of POPE-coated Ti plates. Ti implants with POPE attached non-covalently or covalent via octadecylphosphonic acid (OPA), with OPA alone and uncoated controls were simultaneously implanted intramuscularly in rats for 7, 14 and 56 days. The peri-implant tissue was quantitatively analyzed by immunohistochemistry for total macrophages, tissue macrophages, T cells, antigen-presenting cells and proliferating cells. Overall, both POPE-coated series were comparable to the controls. Furthermore, no differences were found between POPE coating on a covalently linked OPA monolayer and POPE coating dried from solution. Together with earlier in vitro results, this demonstrates the potential of phospholipids for implant surface modification.