@misc{schleede_emphysema_diagnosis_2012, 
author={Schleede, S., Meinel, F.G., Bech, M., Herzen, J., Achterhold, K., Potdevin, G., Malecki, A., Adam-Neumair, S., Thieme, S.F., Bamberg, F., Nikolaou, K., Bohla, A., Yildirim, A.Oe., Loewen, R., Gifford, M., Ruth, R., Eickelberg, O., Reiser, M.F., Pfeiffer, F. and },
title={Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source},
year={2012},
howpublished = {journal article},
doi = {https://doi.org/10.1073/pnas.1206684109},
abstract = {In early stages of various pulmonary diseases, such as emphysema and fibrosis, the change in X-ray attenuation is not detectable with absorption-based radiography. To monitor the morphological changes that the alveoli network undergoes in the progression of these diseases, we propose using the dark-field signal, which is related to small-angle scattering in the sample. Combined with the absorption-based image, the dark-field signal enables better discrimination between healthy and emphysematous lung tissue in a mouse model. All measurements have been performed at 36 keV using a monochromatic laser-driven miniature synchrotron X-ray source (Compact Light Source). In this paper we present grating-based dark-field images of emphysematous vs. healthy lung tissue, where the strong dependence of the dark-field signal on mean alveolar size leads to improved diagnosis of emphysema in lung radiographs.},
note = {Online available at: \url{https://doi.org/10.1073/pnas.1206684109} (DOI). Schleede, S.; Meinel, F.; Bech, M.; Herzen, J.; Achterhold, K.; Potdevin, G.; Malecki, A.; Adam-Neumair, S.; Thieme, S.; Bamberg, F.; Nikolaou, K.; Bohla, A.; Yildirim, A.; Loewen, R.; Gifford, M.; Ruth, R.; Eickelberg, O.; Reiser, M.; Pfeiffer, F.: Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source. Proceedings of the National Academy of Sciences of the United States of America: PNAS. 2012. vol. 109, no. 44, 17880-17885. DOI: 10.1073/pnas.1206684109}}