%0 journal article
%@ 0027-8424
%A Schleede, S., Meinel, F.G., Bech, M., Herzen, J., Achterhold, K., Potdevin, G., Malecki, A., Adam-Neumair, S., Thieme, S.F., Bamberg, F., Nikolaou, K., Bohla, A., Yildirim, A.Oe., Loewen, R., Gifford, M., Ruth, R., Eickelberg, O., Reiser, M.F., Pfeiffer, F.

%D 2012
%J Proceedings of the National Academy of Sciences of the United States of America: PNAS
%N 44
%P 17880-17885 
%R doi:10.1073/pnas.1206684109
%T Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source
%U https://doi.org/10.1073/pnas.1206684109
44 
%X In early stages of various pulmonary diseases, such as emphysema and fibrosis, the change in X-ray attenuation is not detectable with absorption-based radiography. To monitor the morphological changes that the alveoli network undergoes in the progression of these diseases, we propose using the dark-field signal, which is related to small-angle scattering in the sample. Combined with the absorption-based image, the dark-field signal enables better discrimination between healthy and emphysematous lung tissue in a mouse model. All measurements have been performed at 36 keV using a monochromatic laser-driven miniature synchrotron X-ray source (Compact Light Source). In this paper we present grating-based dark-field images of emphysematous vs. healthy lung tissue, where the strong dependence of the dark-field signal on mean alveolar size leads to improved diagnosis of emphysema in lung radiographs.