@misc{chen_sterically_stabilized_2015, 
author={Chen, Y., Angelova, A., Angelov, B., Drechsler, M., Haramus, V.M., Willumeit-Roemer, R., Zou, A.},
title={Sterically stabilized spongosomes for multidrug delivery of anticancer nanomedicines},
year={2015},
howpublished = {journal article},
doi = {https://doi.org/10.1039/c5tb01193k},
abstract = {Multidrug delivery devices are designed to take advantage of the synergistic effects of anticancer agents in combination therapies. Here we report novel liquid crystalline self-assembled nanocarriers enhancing the activity of the phytochemical anticancer agent baicalin (BAI) in combination with Brucea javanica oil (BJO), which ensures safe formulations for clinical applications. Small-angle X-ray scattering (SAXS) and cryogenic transmission electron microscopy (cryo-TEM) evidenced the multicompartment, sponge-type nano-organization of the blank and multidrug-loaded liquid crystalline carriers. Physico-chemical stability of the sponge nanoparticles was achieved through PEGylation of the lipid membranes, which make up the drug nanocarriers. The proposed green nanotechnology for nanocarrier preparation by supramolecular self-assembly provided a multidrug encapsulation efficiency as high as 75%. The apoptosis study with the human lung carcinoma cell line A549 demonstrated improved efficacy of the multidrug delivery nanocarriers in comparison to the single-drug reservoirs. The obtained results evidenced the synergistic anticancer apoptotic effects of the multidrug-loaded nanosponge carriers and suggested the opportunity for in vivo translation towards the treatment of lung, gastrointestinal, and ovarian cancers.},
note = {Online available at: \url{https://doi.org/10.1039/c5tb01193k} (DOI). Chen, Y.; Angelova, A.; Angelov, B.; Drechsler, M.; Haramus, V.; Willumeit-Roemer, R.; Zou, A.: Sterically stabilized spongosomes for multidrug delivery of anticancer nanomedicines. Journal of Materials Chemistry  B. 2015. vol. 3, no. 39, 7734-7744. DOI: 10.1039/c5tb01193k}}