%0 journal article
%@ 1042-7147
%A Yang, J., Feng, Y., Zhang, L.

%D 2015
%J Polymers for Advanced Technologies
%N 12
%P 1370-1377 
%R doi:10.1002/pat.3636
%T Biodegradable carrier/gene complexes to mediate the transfection and proliferation of human vascular endothelial cells
%U https://doi.org/10.1002/pat.3636
12 
%X Artificial vascular scaffolds have been developed and used clinically for many years, but the lack of a living functional layer of human umbilical vein endothelial cells (HUVECs) remains a significant challenge, especially for small diameter artificial blood vessels. Endothelialization of artificial vascular scaffolds has been proved as one of the most potential approaches to improve their hemocompatibility and long-term patency. A variety of non-viral gene carriers have been investigated to mediate the transfection and proliferation of HUVECs. In this mini-review, we will summarize the recent development of the non-viral gene carriers for transfecting HUVECs. The gene transfection with targeting ligand immobilized carriers is a promising approach to enhance endothelialization of artificial vascular scaffolds.